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KMID : 0614619920240010070
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Korean Journal of Gastroenterology
1992 Volume.24 No. 1 p.70 ~ p.79
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A Study on the Change of the HDL Metabolism in the Mechanical Biliary Tract obstruction of Rats
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김종구
안중기/오명성/최수미/전창호/안득수
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Abstract
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Extrahepatic biliary obstruction in humans and in rats leads to change of the total HDL and it's subfractions. To study this mechanism author have used Sprague Dawley rat with transsected common bile duct to measure total HDL and HDL3 by dual
precipitation method. we had observed those rats for 20 days. Other parameters for liver dysfunction also were studied.
@ES The results were as follows:
@EN 1) HDL3 is higher concentration than HDL2 inhuman plasma about over half amount of total HDL but our study in the control rats, total HDL consist of HDL2 89.7±4.5% and HDL3 10.1±1.7%.
2) There were significant (statistical) differences between high total HDL levels of postoperative 5th days group (O. G1) or high those of postoperative 20 th days group (O. G5) and those of control group (p<0.01, p<0.05) but a linear increase
of
total
HDL levels of operation groups were not observed.
3) The differences of HDL3% (HDL3/T-HDL0 between operation groups and control group or either sham operation groups were statistically significant (p<0.01, p0.01) and significant increase of HDL3% of operation groups was observed (p<0.05).
4) The change of HDL3 % of operation groups were observed same puttern in the mechanical biliary tree obstructed rats such as the change of total bilirubin. splcen weight and AST/ALT ratio. These results suggest that high HDL3 levels can use as
an
indicator or a diagnostic marker of obstructive jaundice.
5) In studies of bile juice of operation groups, the HDL3 % of bile juice (84.04%) were higher than those of serum (51.76%) and it means that the form of nascent HDL from liver is almost HDL3.
Above results concluded that there were significant increase in the level of HDL3 in mechanical biliary tract obstruction of rats compare to HDL3 of normal rat and that is probably due to change of apolipoproteins and decrease activtiy of
lecithine
cholesterol acvl transferase.
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